Since the degradation of IkBα is mediated by Cullin RING ubiquitin ligases (CRL), MLN4924/Pevonedistat has demonstrated the capacity to stabilize it, thereby impairing NF-kB signaling in CLL and in diffuse large B-cell lymphoma [9,10]. This evidence concerns the gene NFKB1 and B-cell chronic lymphocytic leukemia.