Since the degradation of IkBα is mediated by Cullin RING ubiquitin ligases (CRL), MLN4924/Pevonedistat has demonstrated the capacity to stabilize it, thereby impairing NF-kB signaling in CLL and in diffuse large B-cell lymphoma [9,10]. The gene discussed is NFKB1; the disease is diffuse large B-cell lymphoma.