ABCG2 and familial pancreatic carcinoma: The EMT causes epigenetic changes and reduces the henT1 expression, a nucleoside transporter that is crucial for gemcitabine uptake; moreover, the EMT overexpressed ABC transporters such as MRP1 and MDR1, which actively efflux the gemcitabine from pancreatic cancer cells, thus decreasing their effectiveness [94].