ZEB1 and leukemia: This confirms that Zeb1 knockdown does not aid in the promotion of Zeb2 in delaying leukemia progression, and that ZEB2 has a specific role in the pathogenesis of AML that is independent of ZEB1. Strikingly, when either Zeb2 or Zeb1 were overexpressed in the hematopoietic system of mice, they significantly increased the extramedullary hematopoiesis development and myeloid compartment expansion, emphasizing their roles in myeloid cell proliferation.