The knockdown of Zeb1 via Cre-mediated knockout in either a Hoxa9/Meisa1 or MLL-AF9 mouse model of AML in in vivo led to tumor progression, suggesting a complex role of ZEB1. Further, Bassani et al. [31] reported the association between ZEB1 and immune modulation. The gene discussed is KMT2A; the disease is acute myeloid leukemia.