Helicobacter pylori (Hp) infection promotes the EMT by enhancing MMP-7 levels, which, in turn, increase the HB-EGF level. Hp cytotoxin-associated gene A (Cag A) reduces the E-cadherin expression and enhances the vimentin and TWIST1 expression in gastric cancer cell linesThe EMT induces resistance against paclitaxel in gastric cancer cell lines. Here, TWIST1 is linked to gastric cancer.