Helicobacter pylori (Hp) infection promotes the EMT by enhancing MMP-7 levels, which, in turn, increase the HB-EGF level. Hp cytotoxin-associated gene A (Cag A) reduces the E-cadherin expression and enhances the vimentin and TWIST1 expression in gastric cancer cell linesThe EMT induces resistance against paclitaxel in gastric cancer cell lines. The gene discussed is HBEGF; the disease is gastric cancer.