Analysis of the top 3D genomic markers associated with CRC using the Search Tool for Retrieval of Interacting Genes (STRING) database revealed eight marker CRC and polyp panels protein–protein interaction networks with hubs on cluster of differentiation (CD)58, mothers against decapentaplegic homologue (SMAD)3, and interleukin 1 receptor (IL1R) (Figure 4A,B). This evidence concerns the gene SMAD3 and colorectal carcinoma.