TACR1 and central nervous system cancer: Moreover, it has been shown that the U-373 MG, U-87 MG, and GAMG glioma cell lines express both the NK-1R-Fl and NK-1R-Tr isoforms [10,28] and that, regardless of the amount of expression of the two isoforms, NK-1R antagonists, for instance L-733,060, L-732,138, and aprepitant, in a concentration-dependent manner, have the same therapeutic effect on GAMG, U-373 MG, and U-87 MG glioma cells, inhibit mitogenesis (as much as 100% inhibition at certain concentrations), and induce apoptosis of glioma cells [29,30,31,32].