In summary, the tumor inflammatory microenvironment is composed of glioma cells, inflammatory cells, and endothelial cells, all express NK-1R and SP, so they all release SP that, when binding to the NK-1R of the cells of the tumor microenvironment, releases different inflammatory interleukins, producing two negative effects, stimulation of tumor growth and depressing the patient’s immunity. Here, TACR1 is linked to glioma.