TACR1 and glioma: In contrast, NK-1R antagonists such as aprepitant or similar drugs penetrate the brain and, in a concentration-dependent manner (high doses), have many therapeutic effects on glioma, such as: inhibiting mitogenesis and inducing apoptosis in glioma cells, counteracting the Warburg effect in glioma cells, inhibiting angiogenesis, having anti-inflammatory effects, counteracting the progression of EMT by decreasing glioma cell migration and invasion (invasion and metastasis), as well as preventing induction of resistance to chemotherapy and/or radiotherapy.