Furthermore, the NK-1R antagonist L-733,060 via NK-1R inhibits the basal kinase activity of Akt; it increases apoptosis and results in caspase-3 cleavage and poly (ADP-ribose) polymerase proteolysis in U-373 MG glioma cells [30] (Figure 2). The gene discussed is AKT1; the disease is central nervous system cancer.