The SP/NK-1R system is involved in the proliferation of glioma cells, has antiapoptotic effects on glioma cells, induces the Warburg effect, triggers angiogenesis, and produces inflammation as well as the progression of EMT, thereby increasing the migration and invasion of glioma cells (infiltration and metastasis) and development of resistance to chemotherapy and/or radiotherapy. Here, TACR1 is linked to glioma.