FIRRM and neoplasm: Genetically-engineered Salmonella, SGN1, which is capable of overexpressing L-methioninase and hydrolyzing methionine and thereby decreasing endogenous methionine and S-adenosyl-methionine (SAM), reduced the tumor growth and metastatic capacity and increased the survival of osteosarcoma subcutaneous-tumor and orthotopic metastatic mouse models, as well as patient-derived organoid and xenograft models, via a reduction in C1orf112 expression and mitochondrial functions [37].