Transcriptomic studies of MSI tumors with advanced sequencing, spatial, and gene expression analyses have detected hubs in the stromal zone, at the tumor–luminal interface of myeloid cells (macrophages, DCs, and granulocytes) and CXCR3-ligand+ effector T cells [71,72] Therefore, the spatial localization of these cell groups is not random: they are strategically placed to coordinate with T cells to interact with tumor cells. This evidence concerns the gene CXCR3 and neoplasm.