An integrated bioinformatics analysis of EBV-associated cell lines, including nasopharyngeal carcinoma, EBV-associated gastric carcinoma, and oral squamous cell carcinoma, identified the TNF-α/NF-κB signaling pathway as common hallmarks in EBV-associated epithelial cancers, providing the critical molecular insights into the mechanisms driving EBV-related epithelial malignancies [13]. Here, NFKB1 is linked to oral cavity squamous cell carcinoma.