NF2 and neoplasm: The NF2 gene is in chr 22q12 and encodes the Merlin protein, a tumor suppressor acting as an important regulator of contact growth inhibition which mediates suppression of several mitogenic signals and whose inactivation, especially by somatic NF2 alterations, plays an important role in the pathogenesis of a wide variety of neoplasms, including MPMs [138,139,140,141,142,143].