Depending on the population studied, approximately 50% of ALMs do carry mutations in BRAF, RAS, or NF1, but the absence of these mutants categorizes the ALM (around 50%) as a distinct group known as the triple-wild-type melanoma (TWM) [13] (Figure 1) TWM-associated mutational genes include KIT, CTNB1, CCND1, KDR, BCL2, MDM2, AKT3, IDH1, GNAQ, GNAS, CDKN2A, CDK4, MITF, RB1, TP53, APC, ERBB2, ERBB3, ABCB5, NUAK2, and TERT [13]. This evidence concerns the gene BRAF and melanoma.