On the other side, SGLT2is are also known to exert systemic effects that are potentially beneficial against cancer, including reduced fat mass and the reduced secretion of insulin, which is a growth factor for cancer cells, reduced advanced glycation end products, and oxidative stress in endothelial cells, leading to reduced systemic inflammation, the reduced accumulation of fat in the liver, and the increased production of ketone bodies, which can also have anti-cancer properties (Figure 3). Here, INS is linked to cancer.