In lung cancer, the first report of SGLT2 expression was published by Ishikawa et al. in 2001 [9], who investigated the expression of SGLT1 and SGLT2 by RT-PCR, and observed an increased expression of SGLT2 in lymph nodes and liver metastasis compared with the primary tumor, but no difference between the primary tumor and adjacent lung tissue [9]. This evidence concerns the gene SLC5A2 and neoplasm.