While the TLRs are primarily known for pro-inflammatory functions, our study identified the engagement of TLR2 receptors by cancer-secreted Hsp70 triggers anti-inflammatory MΦ M2 polarization through the induction of MerTK receptors on MΦs, followed by the association of Hsp70, TLR2, and MerTK. The gene discussed is MERTK; the disease is cancer.