Transcription of CDK20 (CCRK) was activated by ligand-bound androgen receptor (AR) in hepatocellular carcinoma cells (HCCs), and CDK20 in turn upregulated β-catenin signaling, which upregulated the expression of the β-catenin target gene, AR, creating a cycle that induced tumor growth. Here, AR is linked to hepatocellular carcinoma.