In conclusion, current data suggest that DPP3 plays a role in the progression and development of various cancers, and that an overproduction of DPP3 might directly enhance the antioxidant response by allowing newly synthesized NRF2 to escape from the KEAP1 complex, promoting cancer cell growth through metabolic reprograming and increased protection against chemotherapy and radiotherapy. Here, NFE2L2 is linked to cancer.