In this case, when we consider gene pairs such as EMP3-FERMT1 and RBP1-BMP2, we see that while EMP3 is expressed across many immune cells and RBP1 is expressed in endothelial cells, stromal cells, and oligodendrocytes, there is only one major cell type where we see the binary predictive pattern, namely tumor cells. This evidence concerns the gene RBP1 and neoplasm.