Other fc3 genes in the curated set, FERMT1 [54], TMEM100 [55], DYNLT3 [56], EPHB1 [57], IGFBP2 [58], NNMT [59], and SH3GL2 [60] all show direct evidence to a relationship with glioma biology and patient prognosis. This evidence concerns the gene IGFBP2 and central nervous system cancer.