The chromatin modifier enhancer of zeste homolog 2 (EZH2) protein, a subunit of the polycomb repressor complex 2 (PRC2), catalyzes histone H3 lysine 27 trimethylation (H3K27me3) of target gene promotors and silences the transcription of several cancer-related genes via chromatin reorganization [4]. The gene discussed is EZH2; the disease is cancer.