Currently, efforts in breast pathology have been focusing on breast cancer diagnosis and the detection of lymph node metastasis, quantitative analysis of ER, PR, HER2, Ki-67, TILs, mitotic count, and the evaluation of treatment response to neoadjuvant therapy (see review in [148]). The gene discussed is MKI67; the disease is metastatic malignant neoplasm in the lymph nodes.