The expression of MAGE-A4 is notable in head and neck squamous cell carcinoma (HNSCC), synovial sarcoma (SS), Reed–Sternberg cells, serous ovarian neoplasms, myxoid/round cell liposarcoma (MRCLS), NSCLC, urothelial cancer, melanoma and gastroesophageal cancer [34,35,36,37,38,39]. The gene discussed is MAGEA4; the disease is head and neck squamous cell carcinoma.