It lacks the hydroxyl group on carbon 4 of the sphingosine, generating a Th1-biased production of cytokines, together with strong anti-tumor activity against B16-F10 melanoma (which is more aggressive and spreads to several tissues) compared to α-GalCer, which also generated this effect in humanized mice hCD1d-KI, which express human CD1d [101,102]. Here, CD1D is linked to neoplasm.