NF2 and neoplasm: The genetic analysis showed that younger patients with NF2 were more likely to harbor a nucleotide variant in NF2 as the second hit (patients, % = 63 vs. 38), had a higher variant pathogenicity (classification, mean = 4.1 vs. 3.8), and carried more truncating variants in the tumor (variants, % = 73 vs. 50).