The use of long non-coding RNA (LncRNA) transcripts has shown contradictory results; HCG18 has been proven to modulate GPX4 leading to ferroptosis of HCC cells by targeting microRNAs and to increase sorafenib sensitivity, while the knockdown of LncRNA SNHG1 and LncRNA GABPB1-AS1, targeting genes associated with ferroptosis, has been shown to increase iron metabolism accumulation and lipid peroxidation, leading to HCC progression [225,226]. Here, PTGDR is linked to hepatocellular carcinoma.