The expression of HSPA5, EMC2, SLC7A11, HSPB1, GPX4, FANCD2, CISD1, FDFT1, SLC1A5, TFRC, RPL8, DPP4, CS, CARS1, ATP5MC3, ALOX15, ACSL4, and ATL1 was significantly higher in HCC tissue compared with normal liver tissue, while the expression of NFE2L2, MT1G, SAT1, and GLS2 was decreased in HCC tissue compared with normal liver tissue [204]. This evidence concerns the gene ACSL4 and hepatocellular carcinoma.