Moreover, proinflammatory cytokines and Toll-like receptor (TLR) agonists within the HCC TME may regulate several signaling pathways’ (specifically, Stat1, NF-κB, and C/EBPβ) activation, leading in upregulation of hepcidin and inhibition of ferroportin [93]. Here, NFKB1 is linked to hepatocellular carcinoma.