Similarly, Gpx4 depletion in HCC cells induces the ferroptotic death of hepatocytes, creating a tumor-suppressive TME, upregulating immune checkpoints inhibitors, and infiltrating myeloid-derived suppressor cells [196], suggesting that ferroptotic damage-mediated and inflammation-associated immune suppression promotes hepatocarcinogenesis. Here, GPX4 is linked to hepatocellular carcinoma.