ATF4 and hepatocellular carcinoma: Regarding investigation on the role of microRNAs on ferroptosis targeting therapy, MiRNA-214-3p enhances GPX4 protein stability and upregulation of SLC7A11 expression by inhibiting activating transcription factor 4 in HCC, which induces ferroptosis and suppresses hepatocarcinogenesis, and MiR-612 affects HCC oncogenic properties by downregulating coenzyme Q10 and increasing intracellular PUFA and lipid peroxidation processes [227].