Furthermore, a diet high in fatty acids, has been suggested to induce hepatic insulin resistance, resulting in increases in plasma TNF-α and IL-6, in apo-CIII-overexpressing mice, with an increase in apo-CIII playing a major role in liver inflammation and cell death in patients with MASLD [126,127]. The gene discussed is APOC3; the disease is metabolic dysfunction-associated steatotic liver disease.