Exome sequencing analysis in HCC patients revealed 161 putative driver genes associated with 11 modified pathways, including mutations on the TERT promoter (60%), which activate telomerase expression, as well as alterations in WNT/β-Catenin (54%), PI3K/AKT/mTOR (51%), TP53/cell cycle (49%), MAP kinase (43%), hepatic differentiation (34%), epigenetic regulation (32%) chromatin remodeling (28%), oxidative stress (12%), IL-6/JAK/STAT (9%), and TGF-β (5%) [62]. Here, TP53 is linked to hepatocellular carcinoma.