Neoantigens are presented on the cell surface by major histocompatibility complex (MHC) molecules, forming the peptide-MHC (pMHC) complexes that can be recognized by T cell receptors (TCRs), which alongside the expression of co-stimulating molecules and cytokine release, can induce an immune response against cancer [23,24,25,26]. This evidence concerns the gene HLA-C and cancer.