In the current study, we crossed mice with a floxed Itga3 gene [41] into the tamoxifen-inducible KPC:APC mouse model of KRAS-mutated CRC [13], thereby generating mice with a tamoxifen-inducible “molecular switch” to simultaneously knockout α3 in the colon and activate two driver mutations (i.e., loss of Apc and activation of oncogenic Kras). This evidence concerns the gene KRAS and colorectal carcinoma.