In the current study, we crossed mice with a floxed Itga3 gene [41] into the tamoxifen-inducible KPC:APC mouse model of KRAS-mutated CRC [13], thereby generating mice with a tamoxifen-inducible “molecular switch” to simultaneously knockout α3 in the colon and activate two driver mutations (i.e., loss of Apc and activation of oncogenic Kras). The gene discussed is APC; the disease is colorectal carcinoma.