PTK2 and breast carcinoma: α3β1-FAK-Src signaling has also been linked to PI3K/Akt and STAT3 signaling pathways in a murine skin carcinogenesis model [66], and α3β1 signaling through FAK was linked to downstream effectors such as Rac1/PAK1, MAPK and JNK in a mouse model of mammary carcinoma [53], as well as to a YAP-mTOR signaling axis in a mouse model of incisor regeneration [70].