On the other hand, lower expression of the ITGA3 gene (which encodes the α3 integrin subunit) has been correlated with metastasis and poor prognosis in CRC patients [37,38,39], and α3β1 expression was reported to be reduced during the transition of colon tumors from benign to malignant [40]. This evidence concerns the gene ITGA3 and colonic neoplasm.