F. nucleatum infection promoted cell migration and EMT, with upregulation of mesenchymal markers (N-cadherin, Vimentin, SNAI1) and downregulation of E-cadherin. The MIR4435-2HG/miR-296-5p/Akt2/SNAI1 pathway was implicated in EMT induction, linking F. nucleatum infection to oral cancer initiation. Here, CDH2 is linked to lip and oral cavity carcinoma.