Note that RAC1 copy increase was also significantly associated with poorer for OS in five other cancer types [glioblastoma multiforme (GBM), brain lower grade glioma (LGG), lung adenocarcinoma (LUAD), ovarian carcinoma (OV), and uterine corpus endometrial carcinoma (UCEC)], and poorer PFS in four cancer types [GBM, LGG, kidney renal papillary cell carcinoma (KIRP), and sarcoma (SARC)] in addition to HNSCC (Figure 1B, Supplementary Table S1). Here, RAC1 is linked to cancer.