As shown in Figure 3D, while the RAC1-diploid-QM42-PDXs (n = 8) were basically insensitive to EHop-016 throughout the entire treatment (right panel), the RAC1-amp-T76-PDXs (n = 7; left panel) were highly sensitive to EHop-016 with significant tumor inhibition observed as early as day 9, which lasted till the end of experiment, when compared to vehicle treatment. Here, RAC1 is linked to neoplasm.