In contrast, A159V had more restricted effects, which included the upregulation of JMJD7-PLA2G4B (jumonji domain containing 7-phospholipase A2 group IVB), a read-through transcript recently identified as a regulator of AKT signaling and HNSCC cell survival [31]. This evidence concerns the gene PLA2G4B and head and neck squamous cell carcinoma.