Findings in specific cancer types (e.g., colon, breast, melanoma) showed that Rac1 overexpression could promote cancer cell aggressiveness (e.g., adhesion, migration, invasion), reactive oxygen species (ROS) production, glucose metabolism, and stemness, as well as resistance to conventional chemo/radiation therapy [9,10,11,12,13,14,15]. This evidence concerns the gene RAC1 and cancer.