Recent pan-cancer genomic findings from us and others showed that a newly noted RAC1 mutation, namely, RAC1-A159V (NM_006908.4 of 192 amino acids; alternatively marked as A178V per recent TCGA annotation with reference to NM_018890.3 of 211 a.a., www.cbioportal.org), was a specific recurrent hotspot mutation predominantly found in HNSCC [17] and several other cancers including cervical, colorectal, and lung cancers and sarcoma. The gene discussed is RAC1; the disease is cancer.