Using the available proteomic data of HNSCC patient tumors from The Cancer Proteomic Atlas (TCPA; www.cbioportal), we found that A159V-HNSCC patient tumors (n = 2, only two were available) had an average of a 3-fold increase in p-RPS6(Ser235/236) protein expression compared to non-mutated HNSCC tumors (n = 120; proteomic levels of 0.642 vs. −0.241; p < 0.0001 ***, Figure 2C). The gene discussed is RPS6; the disease is cancer.