RAC1 and melanoma: In the TCGA melanoma dataset where primary tumors were sequenced, RAC1-amplification was found in 3.27% (12/367) of cases, whereas RAC1 mutations were found in 5.4% (20/367) of cases, with the majority being the well-known melanoma-prevalent P29S hotspot mutation (TCGA-SKCM Firehose, n = 367).