RAC1 and cancer: Interestingly, among GDSC cancer cell lines from other cancer types, EHT-1864 outliers also appeared to harbor RAC1-amp/gain, including stomach-ECC10 (Amp), ALL-BE13, Breast-OCUB-M, LUAD-NCI-H23, SCLC-DMS-53, and melanoma-A2058 (Gain), and three RAC1-mutated lines with copy increases (ECAD-KYSE-150-gain, Breast-DU-4475 with RAC1-P29S-gain, and melanoma-CHL-1 with RAC1-C18Y-amp) [38,39,40] (Supplementary Figure S3B).