RAC1 and neoplasm: As shown in Figure 5B,C, we found that MeWo-xenografts overexpressing the RAC1-WT gene (mimicking RAC1 amplification) displayed sensitivity to EHop-016 targeting with significant tumor reduction, and apoptosis induction when compared to vehicle treatment (p = 0.0005 ***, n = 4), whereas MeWo-RAC1-P29S xenografts were basically insensitive to EHop-016 treatment (p = n.s., n = 4), which was consistent with our findings in HNSCC P29S-xenograft models.