Specifically, for HNSCC, RAC1 copy increases were also associated with poorer OS (p = 0.0005, log-rank test) and PFS in HNSCC (p = 0.0037, log-rank test) when compared to diploidy patients (Figure 1B, as indicated by red boxes underneath the x-axis, and Figure 1C). This evidence concerns the gene RAC1 and head and neck squamous cell carcinoma.