CYP7A1 and obesity due to melanocortin 4 receptor deficiency: Regarding the other TTP family members (i.e., BRF1 and BRF2), only one study has demonstrated that mice depleted for ZFP36L1 are protected from diet-induced obesity and steatosis via an impaired lipid absorption regulation of Cyp7a1 (cholesterol 7α-hydroxylase) and the bile acid level [174].