CD4 and B-cell chronic lymphocytic leukemia: Univariate analysis revealed that the presence of ≥15 × 109/L clonal B-cells in blood and their IGHV mutational status (UM), together with a greater (≥1.7) sIgM−/sIgM+ MBC ratio, higher PC counts (≥2.1 cells/μL), and lower Tαβ CD4+CD8lo cell numbers (≤35 cells/μL) in blood, were all associated with an increasing CLL clone profile (Figure 2).