Multivariate analysis revealed that from these variables, only the presence of ≥15×109/L clonal B-cells, ≤35 Tαβ CD4+CD8lo cells/μL, and an unmutated IGHV gene status were independent variables to predict CLL with rapidly growing B-cell clones (Table 2). This evidence concerns the gene CD4 and B-cell chronic lymphocytic leukemia.