Zhuang et al. demonstrated that sophoridine, an alkaloid extracted from the seeds of Sophora alopecuroides L., upregulated IL-12α and TNF-α, while it downregulated IL-10 and CD206 via the TLR4/IRF3 signaling pathway in the TME of GC, suggesting that sophoridine promoted TAMs in GC to polarize toward the M1 type and suppressed M2-type polarization [113]. Here, TLR4 is linked to gastric cancer.