As the ‘Warburg effect’ is characterized by a metabolic shift in cancer cells from glucose catabolism via the citric acid cycle to anaerobic glycolysis, even in the presence of adequate oxygen levels, it is conceivable that SUCLG1 downregulation could be a possible candidate in the modulation of HCC and CC metabolic rewiring [32,33]. This evidence concerns the gene SUCLG1 and hepatocellular carcinoma.