In a study investigating the association of RANKL and OPG polymorphisms with Aromatase Inhibitor-Related Musculoskeletal Adverse Events (AI-related MS-AEs) in Chinese breast cancer patients, the SNPs rs7984870 of RANKL and rs2073618 of OPG were associated with development of AI-related MS-AEs [25]. This evidence concerns the gene TNFRSF11B and breast carcinoma.