Objective: In our study, we aimed to investigate the differences in metabolic parameters, serum asprosin and peptide tyrosine tyrosine (PYY) levels in a bipolar disorder manic (BD-M) group, a euthymic group and in healthy controls; we also aimed to evaluate the relationship of asprosin and PYY levels with metabolic parameters and psychopathology in patients. This evidence concerns the gene PYY and bipolar disorder.