Given that in DCM, which is the leading indication for heart transplantation (HTx), the prevalence of functional AAbs against β1-adrenoreceptors (β1AR-AAbs) in the sera of patients with end-stage HF before HTx or left ventricular assist device (LVAD) implantation, can exceed average values of 80% and 90%, respectively, these still insufficiently considered findings deserve more attention [3,4,5,6]. This evidence concerns the gene ADRB1 and hydrops fetalis.