To conclude, in this proof-of-concept case–control study on autoimmunity risk conferred by the MHC locus, we introduced the novel concept of LoHLAD, utilized LoHLAD as an innovative data analysis framework to investigate HLA associations with autoimmunity, and demonstrated that LoHLAD is a significant positive risk factor for the development of pediatric-onset autoimmune rheumatic disease. The gene discussed is HLA-C; the disease is Autoimmunity.