Another potential mechanism underlying the beneficial role of statin therapy as an upstream therapy has also been proposed by Yeh YH et al. [201] involving the activation of the Akt/Nrf2/HO-1 pathway, which delivers heme oxygenase-1 (HO-1)—a potent antioxidant that mediates the suppressive effect of statins on atrial tachycardia-induced structural remodeling in an in vitro model. This evidence concerns the gene HMOX1 and atrial tachycardia.