S100A6 and type 2 diabetes mellitus: A comparative protein expression analysis between healthy subjects without metabolic syndrome (n = 60) and those recently diagnosed with T2DM (n = 87) showed that 90 proteins were significantly dysregulated in the two groups, including 32 proteins that had not previously been associated with T2DM; among the identified proteins was S100A6, which was suggested to play a critical role in the pathogenesis of T2DM [18].