The involvement of zinc in T2DM can also be explained by the crucial roles it plays in many signaling pathways, such as the phosphoinositide 3-kinase/protein kinase B signaling pathway, which promotes glucose uptake in peripheral tissues [5], and the AMP-activated protein kinase pathway, which regulates the energy balance relative to insulin sensitivity and prevents β-cell dysfunction [6]. Here, INS is linked to type 2 diabetes mellitus.