DCM patients harboring DCM-causing variants in high-risk genes (e.g., LMNA, EMD, FLNC, PLN, DSP or TMEM43) should be considered as high-risk patients for SCD, and primary prevention ICD implantation should be considered when left ventricular ejection fraction (LVEF) thresholds are higher than 35% [16,20]. The gene discussed is TMEM43; the disease is familial dilated cardiomyopathy.