FLNC and familial dilated cardiomyopathy: ICD should be considered in DCM patients with an LVEF < 50% and ≥2 risk factors, including syncope, late gadolinium enhancement, inducible sustained monomorphic ventricular tachycardia at programmed electrical stimulation and pathogenic variants in the LMNA, PLN, FLNC and RBM20 genes [11].