These criteria are supplemented by additional weighted criteria, each scoring between 1 and 7 points, organized into six clinical domains, macrovascular venous thromboembolism, macrovascular arterial thrombosis, microvascular, obstetric, cardiac valve, and hematologic, along with two laboratory domains: lupus anticoagulant tests and IgG/IgM anticardiolipin or IgG/IgM β2GP1b. Here, CD40LG is linked to venous thromboembolism.