CD40LG and autoimmune polyendocrinopathy: However, these criteria exhibit shortcomings in that, for example, they do not adequately recognize the difference between IgG and IgM (IgG autoantibodies are better associated with thrombotic APS whereas IgM with obstetric APS), do not emphasize late- versus early-pregnancy morbidities, and lack recognition of small–microvascular clotting manifestations, along with other laboratory or imaging clues for APS.