CD40LG and systemic lupus erythematosus: Finally, in the 1970s, this anticoagulant action was shown to be caused by an acquired immunoglobulin (IgG or IgM) that was partially suppressed by the addition of phospholipids or platelets and was named “lupus anticoagulant” (LA), because it was initially thought to cause bleeding in SLE patients [2].