Hyperglycemia triggers podocyte apoptosis through pathways involving ROS, renin-angiotensin system (RAS), mammalian target of rapamycin (mTOR), and transforming growth factor-beta/SMAD (TGF-β/SMAD) signaling pathway, contributing to podocyte loss and albuminuria in DKD [1]. This evidence concerns the gene REN and diabetic kidney disease.