Other JAK-STAT alterations include changes in IL7R, IL2RB, JAK1, JAK3, SH2B3, FLT3, and TYK2 (Table 3) [24,30,31], and these mutations are commonly multi-subclonal, meaning they are secondary driver events in Ph-like ALL [4]. The gene discussed is SOAT1; the disease is acute lymphoblastic leukemia.