Mutations in genes encoding chromatin modifiers (e.g., ASXL1) or components of the splicing complex (e.g., SF3B1, SRSF2, U2AF1, and ZRSR2), which are commonly associated with AML with myelodysplasia-related changes (AML-MR), were rare. Here, ZRSR2 is linked to acute myeloid leukemia.