Mutations in genes encoding chromatin modifiers (e.g., ASXL1) or components of the splicing complex (e.g., SF3B1, SRSF2, U2AF1, and ZRSR2), which are commonly associated with AML with myelodysplasia-related changes (AML-MR), were rare. The gene discussed is SF3B1; the disease is acute myeloid leukemia.