Although the CD4+ T-cell count and the CD4/CD8 ratio are important immunological markers of HIV progression and non-AIDS disease risk, no significant differences were observed in our study in terms of these markers between patients with and without syphilis coinfection (538.4 vs. 534.6 cells/μL and 0.679 vs. 0.659, respectively) [25]. The gene discussed is CD4; the disease is syphilis.