Diffuse cutaneous sclerosis, the presence of anti-topoisomerase I antibodies, anti-CXCR3 and anti-CXCR4 antibodies, older age, Afro-American ethnicity, low FVC or DLCO and the extent of ILD in HRCT results were all associated with the progression of SSc-ILD [40,41]. This evidence concerns the gene CXCR3 and interstitial lung disease.