INS and Hypoglycemia: Insulin-mediated hypoglycemia is defined based on glycemia ≤ 55 mg/dL, insulinemia ≥ 3 μU/mL, C-peptide levels ≥ 0.6 ng/mL, proinsulinemia ≥ 5 pmol/L and β-hydroxybutyrate levels ≤ 2.7 mmol/l [13].