ABCB1 and breast carcinoma: Additionally, the sponging of miR-221 via GAS5 has been demonstrated to mitigate Adriamycin resistance in breast cancer, specifically through the upregulation of Dickkopf 2 (DDK2) and suppression of P-glycoprotein (ABCB1) expression and the Wnt/β-catenin pathway [59].