For instance, in nonalcoholic fatty liver disease (NAFLD), GAS5 acts as a competing endogenous RNA (ceRNA) for miR-28a-5p, which has been demonstrated to promote pyroptosis through MARCH7-mediated NLRP3 activation, thereby exerting a protective effect [100]. This evidence concerns the gene NLRP3 and metabolic dysfunction-associated steatotic liver disease.