PTEN plays a critical role in tumor suppression through phosphatase-dependent and -independent activities, with one of its more prominent roles being using its phosphatase activity to regulate a crucial pro-survival and cell growth pathway in cancers, i.e., Phosphoinositide 3-Kinase/Phosphorylated-protein Kinase B/Mammalian Target of Rapamycin (PI3KAKT/mTOR) [34]. Here, PTEN is linked to neoplasm.