Specifically, GAS5 acts as a competitive sponge for miR-223-3p, thereby increasing NLRP3 expression and activating the NLRP3 inflammasome, which triggers the secretion of pro-inflammatory cytokines like interleukin-1β (IL-1β) and IL-18, further exacerbating the inflammatory response and PD progression in both in vitro and in vivo models [115]. This evidence concerns the gene GAS5 and Parkinson disease.