Additional findings support a tumor-promoting function of the aberrant GAS5/miR-21 axis via the PTEN/PIK3 or SPRY1/p21 pathways in hepatocellular carcinoma, oral squamous cell carcinoma, bladder cancer cells, and ovarian cancer [45,46,47,48,49]. The gene discussed is GAS5; the disease is hepatocellular carcinoma.