The role of GAS5 and its associated miRNAs in the regulation of cellular proliferation and differentiation has been further demonstrated by GAS5 reducing the migration and invasion of pancreatic cancer via miR-221 repression, specifically through increasing the level of suppressor of cytokine signaling 3 (SOCS3) protein [56]. The gene discussed is GAS5; the disease is familial pancreatic carcinoma.