GAS5 and nervous system disorder: Additionally, GAS5 has been demonstrated to exacerbate the progress of neonatal hydrocephalus through its ceRNA activity on miR-325-3p, which regulates the expression of chaperonin containing T-complex protein 1, subunit 8 (CCT8), a complex that has been demonstrated to play a crucial role in protein quality control as it relates to neurological disease [116].