Considering the control as reference, both in the child and in their parents, the cytokines with elevated levels were IL-1α, IL-1β, IL-5, IL-8, NF-κβ, and interferons (IFN; α, β, and γ), indicating a robust antiviral response initially caused by COVID-19 infection, and probably exacerbated by the lamotrigine-induced TEN in the patient. Here, NFKB1 is linked to toxic epidermal necrolysis.