In our study, we found that the interleukins primarily involved in TEN were IL-4, IL-6, and IL-12, which were modulated (downregulated) by TEN, along with augmented IL-1α, IL-1β, IL-5, IL-8, NF-κβ, and interferons (IFN; α, β, and γ), which were modulated by COVID-19 (Table 2). Here, IFNA1 is linked to toxic epidermal necrolysis.