This study revealed that IL-4, IL-6, and IL-12 play key roles in drug-induced TEN, while COVID-19 infection may lead to elevated levels of IL-1α, IL-1β, IL-5, IL-8, NF-κβ, and interferons (IFN; α, β, and γ). This evidence concerns the gene NFKB1 and toxic epidermal necrolysis.