We addressed if CADhigh patients, grouped by low or high C2 frequencies (C2low: 5.47–21.53%, n = 16; C2high: 21.63–56.75%, n = 16), and relative to diabetes status (C2low or C2high: diabetes−, n = 9; diabetes+, n = 7) (Figure 5A,B), display lower NK cell SPON2 expression and lower PBMC TGFβ transcript levels. Here, SPON2 is linked to diabetes mellitus.