Macrophages can sense oxLDLs through a variety of receptors, such as CD36 and SR-A1 (their transcription is regulated by NF-κB and downgraded by anti-atherosclerotic messengers like polyphenols and curcumin), macrophage receptor with collagenous structure (MARCO), and lectin-like oxLDL receptor-1 (LOX-1), all of whose expression is upregulated in atherosclerosis, leading to increased oxLDL uptake [25]. The gene discussed is CD36; the disease is atherosclerosis.