GSK3B and neoplasm: Likewise, AQP3 was reported to promote EMT through the activation of the PI3K/Akt/SNAIL signaling pathway in gastric cancer cells [63] and was found to contribute to stem-like properties, facilitating tumor growth via the Wnt/glycogen synthase kinase-3 beta (GSK-3β)/β-catenin signaling pathway [64].