MUC5AC and lung cancer: Additionally, AQP5 stimulates lung cancer cell proliferation and migration through the modulation of the epidermal growth factor receptor (EGFR)/ERK/p38 MAPK signaling pathway, while also upregulating the proliferation marker c-myc and increasing MUC5AC mucin production, revealing that AQP5 contributes to a higher metastatic and invasive potential [29].