Additionally, AQP3 overexpression activates the extracellular signal-regulated kinase (ERK)1/2 pathway in prostate cancer cells, leading to increased expression of matrix metalloproteinase-3 (MMP-3), which stimulates cell motility and invasion, further reinforcing AQP3’s contribution to cancer aggressiveness [65]. The gene discussed is MMP3; the disease is Familial prostate cancer.