AQP3 and breast carcinoma: In breast cancer, H2O2 treatment increased AQP3 expression in MCF7 (estrogen- and progesterone-receptor-positive) and SkBr3 (HER2-positive) cells but downregulated AQP3 in SUM159 (triple-negative) cells, indicating that these cells are less responsive to oxidative stress which aligns with their more aggressive and metastatic phenotype.