The cytology results with double staining of p16/Ki-67 were statistically more often noted in the group with RPL compared to healthy pregnant women (p < 0.001, χ2 = 7.9).The increased expression of markers of impaired cell proliferation was observed not only in 52.3% of patients with miscarriage with a normal colposcopic picture, but also in 18.2% of healthy women with successful reproductive outcomes. Here, CDKN2A is linked to spontaneous abortion.