PRKN and Spinocerebellar ataxia type 3: Furthermore, we predict that high levels of NIX, BNIP3, BCL2L13, and metaxins (such MTX2), which are LC3 receptors located on the OMM that directly bind to LC3 and recruit damaged mitochondria to autophagosomes, lead to increased PINK1/Parkin-independent mitophagy (Figure 3B), as suggested in SCA3/MJD.