On the other hand, silencing of CG3066-encoding serine protease Sp7, which is necessary for the activation of PPO1 [148], resulted in a slightly increased lifespan in comparison with the wild-type strain after infection with Streptococcus pneumoniae, but not with Listeria monocytogenes and Salmonella typhimurium, which significantly decreased the lifespan of infected flies, or with Escherichia coli, causing no change in killing rates in CG3066 mutants [149]. This evidence concerns the gene SP7 and infection.