Other studies focused on the role of different molecular weight of HA in pathologies associated to common chronic skin diseases, as atopic dermatitis (AD), proving that, by means of phosphatidylinositol 3-kinases (PI3K)/Protein kinase B (Akt)pathway, the reduction of inflammation response in macrophages, namely RAW 264.7 cells [9,10]. This evidence concerns the gene AKT1 and atopic eczema.